Switch to Main Site
Practice Name

Holistic Veterinary Services

Social Media
Primary Location
32531 N Scottsdale Rd
Scottsdale, AZ 85266
Phone: 928-951-5261

Office Hours

DayMorningAfternoon
MondayMobile Vet9 AM to 6 PM
TuesdayPayson Office9 AM to 6 PM at Payson Office
WednesdayMobile Vet9 AM to 6 PM
ThursdayMobile Vet9 AM to 6 PM
FridayMobile Vet9 AM to 6 PM
SaturdayMobile Vet9 AM to 6 PM
SundayMobile VetClosed
Main Content

Decreased glutathione results in calcium-mediated cell death in PC12.
Jurma OP1, Hom DG, Andersen JK.
Author information
• 1Andrus Gerontology Center, University of Southern California, Los Angeles 90089, USA.
Abstract
Neuronal damage in certain cellular populations in the brain has been linked to oxidative stress accompanied by an elevation in intracellular calcium. Many questions remain about how such oxidative stress occurs and how it affects calcium homeostasis. Glutathione (GSH) is a major regulator of cellular redox status in the brain, and lowered GSH levels have been associated with dopaminergic cell loss in Parkinson's disease (PD). We found that transfection of antisense oligomers directed against glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis, into PC12 cells resulted in decreased GSH and increased levels of ROS. Decreased GSH levels also correlated with an increase in intracellular calcium levels. Data from this study suggest that dopaminergic neurons are very sensitive to decreases in the internal oxidant buffering capacity of the cell caused by reductions in GSH levels, and that alterations in this parameter can result in disruption of calcium homeostasis and cell death. These results may be of particular significance for therapeutic treatment of PD, as those dopaminergic neurons that are spared in this disorder appear to contain the calcium binding protein, calbindin.
 

Sign up using the form below or call 928-951-5261.

Name: *
Email: *
Phone: *

Services We strive to provide complete care for our patients. Learn more about all the services we provide. Make An Appointment We will do our best to accommodate your busy schedule. Schedule an appointment today! Online Forms Our patient forms are available online so they can be completed in the convenience of your own home or office.

Office Hours

Our Calendar CLICK HERE

DayMorningAfternoon
MondayMobile Vet9 AM to 6 PM
TuesdayPayson Office9 AM to 6 PM at Payson Office
WednesdayMobile Vet9 AM to 6 PM
ThursdayMobile Vet9 AM to 6 PM
FridayMobile Vet9 AM to 6 PM
SaturdayMobile Vet9 AM to 6 PM
SundayMobile VetClosed

Pet Selector


Launch Pet Selector

  • 928-951-5261
  • 32531 N Scottsdale Rd Scottsdale, AZ 85266
  • Get Directions
Community Content
Member Topics